Alcohol use Jürgen Rehm, Robin Room, Maristela Monteiro, Gerhard Gmel, Kathryn Graham, Nina Rehn, Christopher T. Sempos, Ulrich Frick and David JerniganSummary Alcohol has long been known as a risk factor for disease. The 1990 Global Burden of Disease (GBD) study (Murray and Lopez 1996a, 1996b) identified alcohol as one of the major global risk factors, accounting for 1.5% of global deaths, 2.1% ..